The primary focus is to provide support to the ongoing
drug discovery program of the institute in the areas of
Pharmacokinetics, ADME and Toxicology and generate preclinical
data.
 |
Development of validated protocols
for HPLC/LC-MS/A-Tof in terms of recovery, presicision,
accuracy and reproducibility. |
|
PK studies of new chemical entities
|
|
Absorption (A), distribution (D),
Metabolism (M), Elimination (E) and protein binding
profile. |
|
Safety pharmacology |
|
Skin Photobiology |
|
Mode of action studies |
|
Stability studies |
|
Pharmacokinetics |
|
Bioavailability/ Bioequivalence studies
|
|
ADME Studies |
|
Phase I Studies |
|
Preparation of Pre-clinical/ Phase
?I Dossiers |
|
In vitro toxicology and mechanistic
studies |
|
Skin biology |
|
In vivo toxicology (as per
OECD guidelines) |
|
Safety pharmacological and stability
studies |
| Sr. NO |
Name |
| 1. |
Rakesh Johri |
| 2. |
Gurdarshan Singh |
| 3. |
Tasduq Abdullah |
| 4. |
Subhash Sharma |
| 5. |
Ashok Tikoo |
| 6. |
Manoj Tikoo |
| Sr. NO |
Name |
Area of Research/Expertise |
E-mail |
| 1. |
Rakesh Johri |
Pharmacokinetics
Drug Metabolism |
rkjohri@iiim.res.in |
| 2. |
Gurdarshan Singh |
Safety Pharmacology
Regulatory Toxicology |
Singh_gd@iiim.res.in |
| 3. |
Tasduq Abdullah |
In vitro Toxicology
Mechanistic studies |
stabdullah@iiim.res.in |
| 4. |
Subhash Sharma |
Pharmacokinetics
Drug Metabolism |
scsharma@iiim.res.in |
| 5. |
Manoj Tikoo |
Pharmacokinetics
Stability studies |
mktikoo@iiim.res.in |
| 6. |
Ashok Tikoo |
Pharmacokinetics |
aktikoo@iiim.res.in |
Supporting Staff:
Milkhi Ram
Kalawati Bhat
|
Pharmacokinetics and General Instrumentation
| Main Instrumentation. |
 |
Shimadzu HPLC system (Class
VP series) |
|
Thermofinningan HPLC System
(Spectra Series) |
|
Waters LC/MS System ?Q ToF (Synapt)
|
|
Thermo Multiscan Spectrum Elisa
Reader |
|
Perkin-Elmer LS 50B Well plate
Spectroflurometer |
|
Perkin-Elmer LS 55 Spectroflurometer
|
|
Shimadzu UV-1601 PC- Spectrophotometer
|
|
Climacell Stability chamber |
|
|
Cell culture facility |
|
Biochemistry lab facility |
|
Safety Pharmacology lab facility
| Main Instrumentation. |
|
Multichannel Polygraph (Expermentia,
Hungry) |
|
Telemetry System (DSI, USA) |
|
Radial Arm Maze (Coulbourn,
USA) |
|
Non Invasive Blood Pressure
System (Kent Scientific, USA) |
|
Double chamber Plethysmograph
(Buxco, UK) |
|
Isolated Organ Bath (Bio-Pack
System, USA) |
|
Hot plate Analgesiometer (Ugo
basile, Italy) |
|
Telethermometer (TSE, Germany) |
|
 |
| 1. |
Identification and development of
natural products as drug bioavailability enhancers.
|
| 2. |
Development of natural products as
modulators of CYP3A/p-glycoprotein. |
| 3. |
Safety Pharmacolgical and regulatory
toxicological studies on various inhouse/sponsored
formulations. |
| 4. |
Cellular and molecular mechanism of
experimentally?induced chronic liver dysfunction
(hepatocellular carcinogenesis, Non Alcoholic Fatty
Liver Disease) and their prevention by natural molecules.
|
| 5. |
UV -irradiation induced photoaging
in human skin cells and its prevention by products
from natural/synthetic sources. |
|
| Sr. NO |
Project Title |
Sponsored by |
Time line |
| 1. |
Major Laboratory Project (MLP 1004)
? In House: Development of plant based agents as
bioavailability enhancers |
Council of Scientific and Industrial
Research |
2008 to 2010 |
| 2. |
CSIR (Extramural): Herbal modulation
of P-gycoprotein/ CYP 3A4 function: implications
in bioavailability of anti-cancer/ anti-viral agents.
|
Council of Scientific and Industrial
Research |
2007-2010 |
| 3. |
Anti-allergic/anti-asthamatic Disorders
Mitigation Mission (NWP0033, Task Force 11th Five
Year Plan). |
Council of Scientific and Industrial
Research |
2008-2012 |
| 4. |
Biochemical and Molecular Studies
on Chemopreventive Mechanism of a Phenylpropanoid
glycoside against chemically induced pro-Hepato-carcinogenic
events. |
Department of Science and Technology
|
2009-2012 |
| 5. |
Develop understanding and control
of SK-II pitera fractionation, benchmarking molecular
bioactivities, chemical characterization and potential
synthetic approaches- Phase ?II. |
Proctor and Gamble, Japan |
2008-2009 |
|
