The chronic inflammatory disease processes are poorly
understood and there is no definite cure for such ailments.
Our research is dedicated to development of new anti-inflammatory,
anti-arthritic and immunomodulatory therapeutics that
addresses inflammation and are devoid of any side effects.
We are also involved in the development of new adjuvants
for vaccines.
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To develop cost effective drugs for
the treatment of the chronic inflammatory disorders
such as rheumatoid arthritis and other inflammatory
diseases and understand their mechanism of action.
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To develop plant based immunomodulatory
agents and establish their mode of action. |
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Development of vaccine adjuvants for
regulation of immune response. |
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Evaluation of anti-inflammatory /
anti-arthritic properties of lead molecules and
their mechanism. |
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Immunological activities of immunomodulating
leads in arthritis and stress (in vitro and in
vivo). |
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Immunophenotyping of T and B cell
surface markers, co-stimulatory markers and T cells
mediated cytokine ( Th1 and Th2 ) generation. |
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Assessment on T cells and their intracellular
and extracellular content of cytokines through flow
cytometric analysis and ELISA. |
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Innate immune response related pro-inflammatory
cytokines,chemokines, growth factors and adhesion
factor like TNF-alpha, IL-1beta , IL-6, GMCSF, MAPs
etc., expression in the neutrophils, macrophages
and other cell types is carried out to see the effect
of the test materials by flowcytometry and ELISA.
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General pharmacological assays related
to inflammation |
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Toxicology: acute, sub-acute, sub-chronic
and chronic toxicity. Genotoxicity: chromosomal
aberrations, sperm abnormalities and micronucleus
assay. |
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Study of cell mediated immune response(
DTH ) and Humoral immune response (primary and secondary).
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Plaque forming cell assay |
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Graft rejection time |
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MTT assay by lymphocyte proliferation
( T –cells & B- cells ) |
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Mitogenic activity ( LPS & CON-A ) |
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Molecular mechanism of immunomodulation |
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Immunology of arthritis and stress |
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In-vivo Anti-inflammatory/ anti-arthritics
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Toxicity study: acute, sub-acute,
sub-chronic and chronic toxicity |
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Genotoxicity |
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General pharmacology in relation to
inflammation |
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BD-LSR Flowcytometer |
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Volume differential meter |
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Hot plate |
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Randall-selitto’s apparatus |
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Activity cage for CNS |
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Polygraph |
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Phase contrast microscope |
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Refrigerated Centrifuge |
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Digital Weighing Balance |
Resourcing of biomolecules from plants, higher fungi and
endotypes using non conventional extraction methods.
In vitro and in vivo screening of plant extracts,
fractions and compounds for their immunomodulatory activity
and their effect on pro-inflammatory cytokines.
Generation of data validating new and novel biological
activities (immunomodulator in disease / drug induced
immune suppression, adaptogen, antistress, hepato -protective,
antiulcer etc ) of different extracts of reputed Malaysian
plant- Tongkat Ali.
Identification of the anti-inflammatory/ anti-arthritic
drug like molecules and to evaluate them for genotoxicity
using techniques like FISH .
Resourcing of biomolecules from plants, higher fungi and
endotypes using non conventional extraction methods like
SCFE and ASE ( CSIR).
Develop understanding and control of SK-II Pitera fractionation,
bench marking Molecular bioactivities, Chemical characterization
and potential synthetic Approaches for Skin care ( Sponsor:
P&G , Japan)
Exploring botanicals from Malaysia: Tongkat ali ( Sponsor:
Holista Biotech)
Newer Scientific Herbal Preparation for Global Positioning
( CSIR Network Project)
Golden Triangle Project for development of standardized,
safe drugs for the national and international herbal market
(Sponsor: AYUSH). |
