Chemical Engineering and Design Division of IIIM, Jammu
is engaged in process development and scale-up of laboratory
processes on pilot plant. Generally extraction processes
are carried out on various herbal/medicinal plants. These
extraction processes are scaled-up from 100/500 g laboratory-scale
to 15-20 kg pilot plant scale processes. Thereafter their
various process parameters are optimized, in order to
maximize the yield of these extractions.
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To Scale-up and optimize laboratory
scale processes, in order to develop cGMP compliant
and commercially viable technologies transferable
to user industry. |
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Develop standardized & quality traditional
medicines which are affordable to community. |
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Develop new rational formulation
of traditional drugs. |
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Generate sufficient data for effective
regularization and control of herbal / traditional
medicines moving into international markets. |
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Generate authentic and accurate, clinically
acceptable data, which can potentially lead to new
IPR’s. |
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Objectives
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To obtain “New process data”
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Improve Yields and Conversions
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Evaluation of Products & By-products
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Preliminary cost estimation
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In order to Maximize yield, Optimisation
of following process parameters is carried out:
Plant Mat./ Solvent Ratio; Temperature of Extraction
Number of Extractions; Time of each extraction. |
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Process Development and scale up of
chemical processes from laboratory to pilot scale.
For this purpose, a multipurpose batch extraction
pilot plant, developed, designed and fabricated
in IIIM Jammu is presently being used. A new computer
controlled cGMP extraction plant has been installed
and commissioned in chemical engineering (IIIM Jammu)
for this purpose. |
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Plant Capacity: To process around
15-20 kg of material per batch. |
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Up scaling carried out from 100 g
to 15/20 kg scale |
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Purpose to reduce STEPS, reduce SOLVENTS
and increase SAFETY of lab. |
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Processes during their scale up on
pilot scale. |
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| Sr. No. |
Name |
Expertise |
E-mail |
| 1. |
Dr. V. K. Koul |
Chemical process development, scale
up and optimization. Designing of multipurpose herbal
drugs extraction plants, Steam distillation units,
dryers and other process equipment like distillation
columns, evaporators, heat exchangers and pressure
vessels. |
vkkoul@iiim.ac.in
|
| 2. |
Mrs. Suman Koul |
Experience in chemical process development,
scale up and optimization. Operation of herbal drugs
extraction plants and other pilot plants |
sumankoul@iiim.ac.in |
| 3. |
Ram Rakha |
Operation and maintenance of extraction
and other chemical engg. Pilot plants |
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| 4. |
Sat Pa |
l Operation and maintenance of extraction
and other chemical engg. pilot plants |
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Scaled up and optimized process on
pilot plant for the extraction of Tinospora cordifolia.
The technology was transferred to M/S Nicholas Piramal,
Mumbai. |
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Scaled up and optimized process on
pilot plant for the extraction of Calcitriol from
Cestrum diurnum. The technology was transferred
to M/S Genova Biotech Ltd. Hyderabad. |
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Scaled up and optimized process on
pilot plant for the extraction of Acteoside from
Colebrookia opp. The technology was
transferred to M/S Ochoa Pharma, New Delhi. |
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Scaled up and optimized process on
pilot plant for the extraction of Hyperforin and
Hypericin from Hypericum perforatum. The
technology was transferred to M/S Nicholas Piramal,
Mumbai. |
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Executed the turnkey project of cGMP
compliant Herbal drugs extraction pilot plant for
M/S Tropical Botanics , Malaysia |
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One old solvent extraction plant along with solvent
recovery system, concentration unit and drying unit
Second complete cGMP Herbal Drugs Extraction unit was
designed, fabricated, installed and commissioned in March
2009 at IIIM, Jammu. The major equipments of the plant
are as follows:-
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Plant material air dryer. |
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Plant material Grinder and screening
system. |
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R.O. plant for process water. |
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Extraction system with condensers
breathers and automatic material handling system.
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Batch solvent storage tanks |
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Solvent recovery unit with condenser,
breather and storage tanks. |
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Wiped film evaporator with accessories.
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Vacuum pan drier. |
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Vacuum tray drier |
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Spray drier |
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Dry Extract sealing unit. |
The plant has been installed on proper steel structure
and following utilities were also installed with appropriate
header lines for inlet and outlet of water, chilled water,
air, vacuum and steam etc.
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Boiler – Cap- 600kg/h (Thermax make)
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Cooling tower |
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Chilling plant |
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Air compressor |
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Vacuum pumps |
The entire plant is controlled by PLC/computer with by
pass lines for manual operation.
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Process development for extraction
of Stevioside/Rebaudioside rich extract from Stevia
(Industry Linkage- Sahara India) |
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Extraction step optimized on pilot
scale. |
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Color absorption/adsorption and final
concentration and drying in development stage. |
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Aim to obtain white crystalline powder
extract |
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SIMAP Project for Steam distillation
& Fractionation of Mint oil at KanyaKumari |
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National facility project “ cGMP pilot
plant for Extraction, Formulation and Packaging
of Traditional (ISM) herbal Medicinal formulation”
financed by IIIM Jammu, DST New Delhi, and Ayush. |
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