Bio-organic Chemistry gropup deals with natural products,
biocatalysis, organocatalysis, glyco-chemistry, organic
synthesis etc. Prospecting the plant as well as microbial
biodiversity of the region as well as other parts of the
country is one of the broad objectives of the group. The
natural plant biodiversity specifically related to medicinal
plants used in the traditional medicine is one of the
major activities comprising detailed chemistry, identifying
bioactive components/fractions/marker molecules, standardization
etc. besides, generation of focused libraries based on
natural product scaffolds, which has resulted in identifying
several bioactive lead molecules.
In concordance with the missions and goals of the institute,
the bio-organic group strives to contribute towards its
development and recognition as one of the premier national
institutes in the area of drug development, natural products
and bio-catalysis. Some important goals set by the group
include:
 |
Identification of new lead molecules
in anti-cancer, anti-inflammatory, anti-arthritic,
anti-bacterial, anti-fungal, anti-diabetic, anti-oxidant,
immunomodulation, efflux pump inhibition, bio-enhancers
etc. |
|
Generation of IPR as well as patenting
of the bioactive molecules as NCEs. |
|
New developments in synthetic chemistry,
organocatalysis and glycochemistry. |
|
Development of novel industrial biocatalysts
and processes based on them. |
|
Development of green methodologies. |
 |
The group has competencies/expertise in the following
area
|
Natural product Chemistry (medicinal
and aromatic plants) (Extraction using conventional
and non-conventional approaches, isolation, characterization,
standardization, quality evaluation of plant based
formulations, extracts, fractions and pure isolates)
. |
|
Compound library generation (chemical
modifications) based on natural products and establishment
of structure activity relationships |
|
Molecular structure elucidation. |
|
Development of new and novel methodologies
for the preparation of chemicals of importance using
Organic synthesis, Glycochemistry, Organocatalysis
etc. |
|
Biotransformations aided through lipases,
esterases, dehydrogenases, nitrilases, peroxidases
and glycosidases |
|
| Sr. NO |
Name |
Expertise |
E-mail |
| 1. |
S. Koul |
Drug Development, Natural Product
Chemistry, Synthetic Chemistry, Enzyme Chemistry,
Perfumery Chemistry, Glycochemistry and Molecular
Modeling. |
skoul@iiim.res.in |
| 2. |
J.L. Koul |
Drug Development, Natural Product
Chemistry, Synthetic Chemistry and Enzyme Chemistry, |
jlkoul@iiim.res.in
|
| 3. |
A.K. Tripathi |
Synthetic and Medicinal Chemistry
|
aktripathi@iiim.res.in
|
| 4. |
P.L. Sangwan |
Natural Product Chemistry, Drug Development
and Synthetic Chemistry |
plsangwan@iiim.res.in |
| 5. |
B. Singh |
Chemo-enzymatic Studies of biologically
active intermediates, Natural Product Chemistry
and Synthetic Chemistry. |
bsingh@iiim.res.in
|
| 6. |
S. Singh |
Technical Assistance |
|
|
|
Drug Development |
|
Rational drug design using Molecular
Modeling. |
|
Development of focused semi-synthetic
libraries based upon natural product scaffolds and
establishment of possible SARs, molecular modes
of action etc. |
|
Synthesis of bio-molecules. |
|
New developments and methodologies
in carbohydrate chemistry. |
|
Organo- and Heterogenous catalysis
for diversity oriented synthesis (DOS). |
|
Identification of novel biocatalysts.
|
|
Development of biocatalytic process
for molecules of industrial importance. |
|
HPLC units with normal, reverse phase
and chiral columns. |
|
Centrifuge. |
|
Freeze drier. |
|
Hydrogenation apparatus. |
|
Flash chromatographs bench as well
as fully automatic with loading capacity up to 100
g batch. |
|
Low temperature deep freezers (up
to multiliter capacity). |
|
Sonicators. |
|
High and low temperature probes for
carrying out reaction at desired temperature. |
|
Ice-Maker |
|
TLC Spraying cabinets with plate heating
facility. |
|
|
Generation of focused libraries based
upon following natural product scaffolds such as
terpenoids (mono-, di- and triterpenoids), alkaloids,
withanolide, steroids, amides, coumarins, flavonoids,
lignans, phenolics etc. for identifying lead molecules,
optimization, identification of their molecular
targets, mode of action in the area of cancer, inflammation,
anti-bacterial, anti-fungal, immunomodulation, CNS/CVS,
, efflux pump inhibition, bio-enhancers etc. |
|
Isolation and characterization of
novel natural products of plant origin. |
|
Development of novel protection methodologies,
glycosylation, chemical transformation for the preparation
of bioactive molecules. |
|
Application of organocatalysis in
useful chemical transformations |
|
Generation of a biocatalytic toolbox
comprising lipases, esterases, dehydrogenases, nitrilases,
peroxidases and glycosidases for the biotransformation
of industrially important drugs, their precursors,
auxiliaries, perfumery chemicals etc. |
|
Development of chemo-enzymatic methods
for the preparation of chiral biomolecules |
|
Identification and development of
endophytic sources for industrially important molecules
|
|
3D-structure prediction cum determination
of proteins/w enzymes using in silico lab facility,
QSAR studies of bioactives. |
|
|
Development of novel target based
anticancer therapeutics (SIP-0027) |
|
Exploitation of India’s rich microbial
diversity (NWP-006) |
|
Screening of microorganisms for the
development of a biocatalyst tool box with emphasis
on novel bacterial cellulase, cold active protease
and lipase enzymes for important bio-transformations
(MLP-007). |
|
Golden Triangle Project (CSIR, AYUSH
and ICMR) Development of anti-bacterial agent for
oral health care (SSP-0415) |
|
Discovery and pre-clinical studies
of new bioactive molecules (natural and semi-synthetic)
and traditional preparations (NWP-0037) |
|
Isolation and identification of bioactive
principle/s from plant source for rheumatoid arthritis
(CLP-0304) |
|
Drug target development using in silico
biology (CMM-0017) |
|
Exploring botanicals fro Malaysia-Tonkat
Ali (SSP-0414) |
|
Enzymatic Screening of molecules (CNP-1300) |
|
